Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

Chronic alcohol exposure increased hepatic receptor-interacting protein kinase (RIP) 3 expression and necroptosis in the liver but its mechanisms are unclear. In the present study, we demonstrated that chronic alcohol feeding plus binge (Gao-binge) increased RIP3 but not RIP1 protein levels in mouse...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Wang, Shaogui, Ni, Hong-Min, Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Nawabi, Atta, Komatsu, Masaaki, Huang, Heqing, Ding, Wen-Xing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951242/
https://ncbi.nlm.nih.gov/pubmed/26769846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6893
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