Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice

Alcoholic liver disease claims two million lives per year. We previously reported that autophagy protected against alcohol-induced liver injury and steatosis by removing damaged mitochondria. However, the mechanisms for removal of these mitochondria are unknown. Parkin is an evolutionarily conserved...

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Bibliographic Details
Published in:Am J Physiol Gastrointest Liver Physiol
Main Authors: Williams, Jessica A., Ni, Hong-Min, Ding, Yifeng, Ding, Wen-Xing
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
Subjects:
Liver and Biliary Tract Physiology/Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556950/
https://ncbi.nlm.nih.gov/pubmed/26159696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00108.2015
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