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Original Research: Diametric effects of hypoxia on pathophysiology of sickle cell disease in a murine model

Hypoxia causes erythrocyte sickling in vitro; however, its role in the pathophysiology of sickle cell disease is poorly understood. We report that hypoxia rapidly decreased oxygen saturation in transgenic sickle cell disease mice, but this effect was immediately buffered by a robust ventilatory resp...

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Podrobná bibliografie
Vydáno v:Exp Biol Med (Maywood)
Hlavní autoři: Tan, Fang, Ghosh, Samit, Mosunjac, Mario, Manci, Elizabeth, Ofori-Acquah, Solomon Fiifi
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950388/
https://ncbi.nlm.nih.gov/pubmed/27026725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370216642046
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