Global Gene Expression Profiling of Endothelium Exposed to Heme Reveals an Organ-Specific Induction of Cytoprotective Enzymes in Sickle Cell Disease

BACKGROUND: Sickle cell disease (SCD) is characterized by hemolysis, vaso-occlusion and ischemia reperfusion injury. These events cause endothelial dysfunction and vasculopathies in multiple systems. However, the lack of atherosclerotic lesions has led to the idea that there are adaptive mechanisms...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ghosh, Samit, Tan, Fang, Yu, Tianwei, Li, Yuhua, Adisa, Olufolake, Mosunjac, Mario, Ofori-Acquah, Solomon F.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2011
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069101/
https://ncbi.nlm.nih.gov/pubmed/21483798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018399
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