Extracellular hemin crisis triggers acute chest syndrome in sickle mice

The prevention and treatment of acute chest syndrome (ACS) is a major clinical concern in sickle cell disease (SCD). However, the mechanism underlying the pathogenesis of ACS remains elusive. We tested the hypothesis that the hemolysis byproduct hemin elicits events that induce ACS. Infusion of a lo...

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Bibliografiska uppgifter
Huvudupphovsmän: Ghosh, Samit, Adisa, Olufolake Adetoro, Chappa, Prasanthi, Tan, Fang, Jackson, Kesmic Ann, Archer, David Robert, Ofori-Acquah, Solomon Fiifi
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809772/
https://ncbi.nlm.nih.gov/pubmed/24084741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64578
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