High NOTCH activity induces radiation resistance in non small cell lung cancer

BACKGROUND AND PURPOSE: Patients with advanced NSCLC have survival rates <15%. The NOTCH pathway plays an important role during lung development and physiology but is often deregulated in lung cancer, making it a potential therapeutic target. We investigated NOTCH signaling in NSCLC and hypothesi...

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Veröffentlicht in:Radiother Oncol
Hauptverfasser: Theys, Jan, Yahyanejad, Sanaz, Habets, Roger, Span, Paul, Dubois, Ludwig, Paesmans, Kim, Kattenbeld, Bo, Cleutjens, Jack, Groot, Arjan J., Schuurbiers, Olga C.J., Lambin, Philippe, Bussink, Jan, Vooijs, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948666/
https://ncbi.nlm.nih.gov/pubmed/23891097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2013.06.020
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