Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens

[Image: see text] Although classical, negatively charged antifolates such as methotrexate possess high affinity for the dihydrofolate reductase (DHFR) enzyme, they are unable to penetrate the bacterial cell wall, rendering them poor antibacterial agents. Herein, we report a new class of charged prop...

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Publicat a:ACS Med Chem Lett
Autors principals: Scocchera, Eric, Reeve, Stephanie M., Keshipeddy, Santosh, Lombardo, Michael N., Hajian, Behnoush, Sochia, Adrienne E., Alverson, Jeremy B., Priestley, Nigel D., Anderson, Amy C., Wright, Dennis L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948012/
https://ncbi.nlm.nih.gov/pubmed/27437079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00120
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