Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens

[Image: see text] Although classical, negatively charged antifolates such as methotrexate possess high affinity for the dihydrofolate reductase (DHFR) enzyme, they are unable to penetrate the bacterial cell wall, rendering them poor antibacterial agents. Herein, we report a new class of charged prop...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Scocchera, Eric, Reeve, Stephanie M., Keshipeddy, Santosh, Lombardo, Michael N., Hajian, Behnoush, Sochia, Adrienne E., Alverson, Jeremy B., Priestley, Nigel D., Anderson, Amy C., Wright, Dennis L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948012/
https://ncbi.nlm.nih.gov/pubmed/27437079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00120
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