A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients homozygous for the CFTR Phe508del mutation. Here...

Full description

Saved in:
Bibliographic Details
Published in:Cell Death Differ
Main Authors: Tosco, A, De Gregorio, F, Esposito, S, De Stefano, D, Sana, I, Ferrari, E, Sepe, A, Salvadori, L, Buonpensiero, P, Di Pasqua, A, Grassia, R, Leone, C A, Guido, S, De Rosa, G, Lusa, S, Bona, G, Stoll, G, Maiuri, M C, Mehta, A, Kroemer, G, Maiuri, L, Raia, V
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947669/
https://ncbi.nlm.nih.gov/pubmed/27035618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.22
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items