A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients homozygous for the CFTR Phe508del mutation. Here...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Tosco, A, De Gregorio, F, Esposito, S, De Stefano, D, Sana, I, Ferrari, E, Sepe, A, Salvadori, L, Buonpensiero, P, Di Pasqua, A, Grassia, R, Leone, C A, Guido, S, De Rosa, G, Lusa, S, Bona, G, Stoll, G, Maiuri, M C, Mehta, A, Kroemer, G, Maiuri, L, Raia, V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947669/
https://ncbi.nlm.nih.gov/pubmed/27035618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.22
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