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Online Hydrophobic Interaction Chromatography-Mass Spectrometry for Top-down Proteomics

Recent progress in top-down proteomics has led to a demand for mass spectrometry (MS)-compatible chromatography techniques to separate intact proteins using volatile mobile phases. Conventional hydrophobic interaction chromatography (HIC) provides high-resolution separation of proteins under non-den...

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Publicat a:Anal Chem
Autors principals: Chen, Bifan, Peng, Ying, Valeja, Santosh G., Xiu, Lichen, Alpert, Andrew J., Ge, Ying
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947469/
https://ncbi.nlm.nih.gov/pubmed/26729044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b04285
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