Epithelial-mesenchymal transition is associated with a distinct tumor microenvironment including elevation of inflammatory signals and multiple immune checkpoints in lung adenocarcinoma

PURPOSE: Promising results in the treatment of NSCLC have been seen with agents targeting immune checkpoints, such as PD-1 or PD-L1. However, only a select group of patients respond to these interventions. The identification of biomarkers that predict clinical benefit to immune checkpoint blockade i...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Lou, Yanyan, Diao, Lixia, Cuentas, Edwin Roger Parra, Denning, Warren L., Chen, Limo, Fan, Youhong, Byers, Lauren A., Wang, Jing, Papadimitrakopoulou, Vassiliki, Behrens, Carmen, Rodriguez, Jaime Canales, Hwu, Patrick, Wistuba, Ignacio I., Heymach, John V., Gibbons, Don L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947453/
https://ncbi.nlm.nih.gov/pubmed/26851185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1434
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