Targeting DNA damage response promotes anti-tumor immunity through STING-mediated T-cell activation in small cell lung cancer

Despite recent advances in the use of immunotherapy, only a minority of small cell lung cancer (SCLC) patients respond to immune checkpoint blockade (ICB). Here, we show that targeting DNA damage response (DDR) proteins, poly ADP-ribose polymerase (PARP) and checkpoint kinase 1 (CHK1) significantly...

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Publicado no:Cancer Discov
Main Authors: Sen, Triparna, Rodriguez, B. Leticia, Chen, Limo, Corte, Carminia Della, Morikawa, Naoto, Fujimoto, Junya, Cristea, Sandra, Nguyen, Thuyen, Diao, Lixia, Li, Lerong, Fan, Youhong, Yang, Yongbin, Wang, Jing, Glisson, Bonnie S., Wistuba, Ignacio I., Sage, Julien, Heymach, John V., Gibbons, Don L., Byers, Lauren A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563834/
https://ncbi.nlm.nih.gov/pubmed/30777870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1020
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