A patient-derived, pan-cancer EMT signature identifies global molecular alterations and immune target enrichment following epithelial to mesenchymal transition

PURPOSE: We previously demonstrated the association between epithelial-to-mesenchymal transition (EMT) and drug response in lung cancer using an EMT signature derived in cancer cell lines. Given the contribution of tumor microenvironments to EMT, we extended our investigation of EMT to patient tumor...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Mak, Milena P., Tong, Pan, Diao, Lixia, Cardnell, Robert J., Gibbons, Don L., William, William N., Skoulidis, Ferdinandos, Parra, Edwin R., Rodriguez-Canales, Jaime, Wistuba, Ignacio I., Heymach, John V., Weinstein, John N., Coombes, Kevin R., Wang, Jing, Byers, Lauren Averett
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737991/
https://ncbi.nlm.nih.gov/pubmed/26420858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0876
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