Knockdown of Triglyceride Synthesis Does Not Enhance Palmitate Lipotoxicity or Prevent Oleate-Mediated Rescue in Rat Hepatocytes

Experiments in a variety of cell types, including hepatocytes, consistently demonstrate the acutely lipotoxic effects of saturated fatty acids, such as palmitate (PA), but not unsaturated fatty acids, such as oleate (OA). PA+OA co-treatment fully prevents PA lipotoxicity through mechanisms that are...

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Bibliografische gegevens
Gepubliceerd in:Biochim Biophys Acta
Hoofdauteurs: Leamy, Alexandra K., Hasenour, Clinton M., Egnatchik, Robert A., Trenary, Irina A., Yao, Conghui, Patti, Gary J., Shiota, Masakazu, Young, Jamey D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947436/
https://ncbi.nlm.nih.gov/pubmed/27249207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2016.05.013
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