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ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
Palmitate overload induces hepatic cell dysfunction characterized by enhanced apoptosis and altered citric acid cycle (CAC) metabolism; however, the mechanism of how this occurs is incompletely understood. We hypothesize that elevated doses of palmitate disrupt intracellular calcium homeostasis resu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4099508/ https://ncbi.nlm.nih.gov/pubmed/25061559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.05.004 |
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