High Throughput Combinatorial Formatting of PcrV Nanobodies for Efficient Potency Improvement

Improving potencies through concomitant blockage of multiple epitopes and avid binding by fusing multiple (different) monovalent Nanobody building blocks via linker sequences into one multivalent polypeptide chain is an elegant alternative to affinity maturation. We explored a large and random forma...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: De Tavernier, Evelyn, Detalle, Laurent, Morizzo, Erika, Roobrouck, Annelies, De Taeye, Severine, Rieger, Melanie, Verhaeghe, Tom, Correia, Andreia, Van Hegelsom, Rob, Figueirido, Rita, Noens, Jeroen, Steffensen, Søren, Stöhr, Thomas, Van de Velde, Willem, Depla, Erik, Dombrecht, Bruno
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Protein Structure and Folding
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946937/
https://ncbi.nlm.nih.gov/pubmed/27226529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684241
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