Trivalency of a Nanobody Specific for the Human Respiratory Syncytial Virus Fusion Glycoprotein Drastically Enhances Virus Neutralization and Impacts Escape Mutant Selection

ALX-0171 is a trivalent Nanobody derived from monovalent Nb017 that binds to antigenic site II of the human respiratory syncytial virus (hRSV) fusion (F) glycoprotein. ALX-0171 is about 6,000 to 10,000 times more potent than Nb017 in neutralization tests with strains of hRSV antigenic groups A and B...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Palomo, Concepción, Mas, Vicente, Detalle, Laurent, Depla, Erik, Cano, Olga, Vázquez, Mónica, Stortelers, Catelijne, Melero, José A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075053/
https://ncbi.nlm.nih.gov/pubmed/27550346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00842-16
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