High Throughput Combinatorial Formatting of PcrV Nanobodies for Efficient Potency Improvement

Improving potencies through concomitant blockage of multiple epitopes and avid binding by fusing multiple (different) monovalent Nanobody building blocks via linker sequences into one multivalent polypeptide chain is an elegant alternative to affinity maturation. We explored a large and random forma...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: De Tavernier, Evelyn, Detalle, Laurent, Morizzo, Erika, Roobrouck, Annelies, De Taeye, Severine, Rieger, Melanie, Verhaeghe, Tom, Correia, Andreia, Van Hegelsom, Rob, Figueirido, Rita, Noens, Jeroen, Steffensen, Søren, Stöhr, Thomas, Van de Velde, Willem, Depla, Erik, Dombrecht, Bruno
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946937/
https://ncbi.nlm.nih.gov/pubmed/27226529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684241
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