High Throughput Combinatorial Formatting of PcrV Nanobodies for Efficient Potency Improvement

Improving potencies through concomitant blockage of multiple epitopes and avid binding by fusing multiple (different) monovalent Nanobody building blocks via linker sequences into one multivalent polypeptide chain is an elegant alternative to affinity maturation. We explored a large and random forma...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: De Tavernier, Evelyn, Detalle, Laurent, Morizzo, Erika, Roobrouck, Annelies, De Taeye, Severine, Rieger, Melanie, Verhaeghe, Tom, Correia, Andreia, Van Hegelsom, Rob, Figueirido, Rita, Noens, Jeroen, Steffensen, Søren, Stöhr, Thomas, Van de Velde, Willem, Depla, Erik, Dombrecht, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946937/
https://ncbi.nlm.nih.gov/pubmed/27226529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684241
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