A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors

[Image: see text] Human macrophage migration inhibitory factor (MIF) is both a keto–enol tautomerase and a cytokine associated with numerous inflammatory diseases and cancer. Consistent with observed correlations between inhibition of the enzymatic and biological activities, discovery of MIF inhibit...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Cisneros, José A., Robertson, Michael J., Valhondo, Margarita, Jorgensen, William L
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945996/
https://ncbi.nlm.nih.gov/pubmed/27299179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b04910
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