Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is implicated in the regulation of inflammation, cell proliferation, and neurological disorders. MIF is also an enzyme that functions as a keto-enol tautomerase. Most potent MIF tautomerase inhibitors incorporate a pheno...

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Pubblicato in:ChemMedChem
Autori principali: Trivedi-Parmar, Vinay, Robertson, Michael J., Cisneros, José A., Krimmer, Stefan G., Jorgensen, William L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990473/
https://ncbi.nlm.nih.gov/pubmed/29575754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800158
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