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Phenolic Hydrazones are Potent Inhibitors of Macrophage Migration Inhibitory Factor Proinflammatory Activity and Survival Improving Agents in Sepsis()
A series of phenolic hydrazones were synthesized and evaluated for their inhibition of MIF tautomerase activity. Compound 7 emerged as a potent inhibitor of MIF with an IC(50) of 130 nM. Compound 7 dose dependently suppressed TNFα secretion from lipopolysaccharide stimulated macrophages. The therape...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5710735/ https://ncbi.nlm.nih.gov/pubmed/17385848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061477+ |
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