Carregant...
Phenolic Hydrazones are Potent Inhibitors of Macrophage Migration Inhibitory Factor Proinflammatory Activity and Survival Improving Agents in Sepsis()
A series of phenolic hydrazones were synthesized and evaluated for their inhibition of MIF tautomerase activity. Compound 7 emerged as a potent inhibitor of MIF with an IC(50) of 130 nM. Compound 7 dose dependently suppressed TNFα secretion from lipopolysaccharide stimulated macrophages. The therape...
Guardat en:
| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5710735/ https://ncbi.nlm.nih.gov/pubmed/17385848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061477+ |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|