Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors

[Image: see text] We report the crystal structures of two inhibitors of Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) with nanomolar K(i)’s, analyze their interactions with the active site of PfMIF, and provide explanations regarding their selectivity of PfMIF versus human MIF...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pantouris, Georgios, Rajasekaran, Deepa, Garcia, Alvaro Baeza, Ruiz, Victor G., Leng, Lin, Jorgensen, William L., Bucala, Richard, Lolis, Elias J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207548/
https://ncbi.nlm.nih.gov/pubmed/25268646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501168q
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados