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Structural Plasticity in the C‑Terminal Region of Macrophage Migration Inhibitory Factor‑2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor
We report the first reversible and selective small molecule inhibitor of pro-inflammatory protein macrophage migration inhibitory factor-2 (also known as MIF-2 or D-DT). 4-(3-Carboxyphenyl)-2,5pyridinedicarboxylic acid (4-CPPC) shows competitive binding with a 13fold selectivity for human MIF-2 vers...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123015/ https://ncbi.nlm.nih.gov/pubmed/29847104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00344 |
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