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A fluorescence polarization binding assay to identify inhibitors of flavin-dependent monooxygenases

N-hydroxylating monooxygenases (NMOs) are essential for pathogenesis in fungi and mycobacteria. NMOs catalyze the hydroxylation of lysine and ornithine in the biosynthesis of hydroxamate-containing siderophores. Inhibition of kynurenine monooxygenase (KMO), which catalyzes the conversion of l-kynure...

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Detalhes bibliográficos
Main Authors: Qi, Jun, Kizjakina, Karina, Robinson, Reeder, Tolani, Karishma, Sobrado, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903666/
https://ncbi.nlm.nih.gov/pubmed/22410281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2012.03.002
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