Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system

Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. However, whether precise disruption of Mstn in livestock can be achieved and safely used to improve meat productivity has not been proven. We applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Guo, Rihong, Wan, Yongjie, Xu, Dan, Cui, Libin, Deng, Mingtian, Zhang, Guomin, Jia, Ruoxin, Zhou, Wenjun, Wang, Zhen, Deng, Kaiping, Huang, Mingrui, Wang, Feng, Zhang, Yanli
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945924/
https://ncbi.nlm.nih.gov/pubmed/27417210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29855
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