Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system

Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. However, whether precise disruption of Mstn in livestock can be achieved and safely used to improve meat productivity has not been proven. We applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and...

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Udgivet i:Sci Rep
Main Authors: Guo, Rihong, Wan, Yongjie, Xu, Dan, Cui, Libin, Deng, Mingtian, Zhang, Guomin, Jia, Ruoxin, Zhou, Wenjun, Wang, Zhen, Deng, Kaiping, Huang, Mingrui, Wang, Feng, Zhang, Yanli
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945924/
https://ncbi.nlm.nih.gov/pubmed/27417210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29855
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