The Role of Cholesterol in Driving IAPP-Membrane Interactions

Our knowledge of the molecular events underlying type 2 diabetes mellitus—a protein conformational disease characterized by the aggregation of islet amyloid polypeptide (IAPP) in pancreatic β cells—is limited. However, amyloid-mediated membrane damage is known to play a key role in IAPP cytotoxicity...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Sciacca, Michele F.M., Lolicato, Fabio, Di Mauro, Giacomo, Milardi, Danilo, D’Urso, Luisa, Satriano, Cristina, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2016
Assuntos:
Membranes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944530/
https://ncbi.nlm.nih.gov/pubmed/27410742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.05.050
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