α-Helical Structures Drive Early Stages of Self-Assembly of Amyloidogenic Amyloid Polypeptide Aggregate Formation in Membranes

The human islet amyloid polypeptide (hIAPP) is the primary component in the toxic islet amyloid deposits in type-2 diabetes. hIAPP self-assembles to aggregates that permeabilize membranes and constitutes amyloid plaques. Uncovering the mechanisms of amyloid self-assembly is the key to understanding...

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Autori principali: Pannuzzo, Martina, Raudino, Antonio, Milardi, Danilo, La Rosa, Carmelo, Karttunen, Mikko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784961/
https://ncbi.nlm.nih.gov/pubmed/24071712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02781
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