Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface

The life cycle of the human parvovirus adeno-associated virus (AAV) is orchestrated by four Rep proteins. The large Rep proteins, Rep78 and Rep68, are remarkably multifunctional and display a range of biochemical activities, including DNA binding, nicking, and unwinding. Functionally, Rep78 and Rep6...

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Библиографические подробности
Опубликовано в: :J Virol
Главные авторы: Bardelli, Martino, Zárate-Pérez, Francisco, Agúndez, Leticia, Linden, R. Michael, Escalante, Carlos R., Henckaerts, Els
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Genome Replication and Regulation of Viral Gene Expression
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944284/
https://ncbi.nlm.nih.gov/pubmed/27170758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00356-16
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