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Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation
Adeno-associated virus (AAV) nonstructural proteins Rep78 and Rep68 carry out all DNA transactions that regulate the AAV life cycle. They share two multifunctional domains: an N-terminal origin binding/nicking domain (OBD) from the HUH superfamily and a SF3 helicase domain. A short linker of ~20 ami...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4636433/ https://ncbi.nlm.nih.gov/pubmed/26314310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00610 |
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