The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA(+) machine that can switch between oligomeric states

The adeno-associated virus (AAV) non-structural Rep proteins catalyze all the DNA transactions required for virus viability including, DNA replication, transcription regulation, genome packaging, and during the latent phase, site-specific integration. Rep proteins contain two multifunctional domains...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Santosh, Vishaka, Musayev, Faik N, Jaiswal, Rahul, Zárate-Pérez, Francisco, Vandewinkel, Bram, Dierckx, Caroline, Endicott, Molly, Sharifi, Kamyar, Dryden, Kelly, Henckaerts, Els, Escalante, Carlos R
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Structural Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736791/
https://ncbi.nlm.nih.gov/pubmed/33270897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1133
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