The Interdomain Linker of AAV-2 Rep68 Is an Integral Part of Its Oligomerization Domain: Role of a Conserved SF3 Helicase Residue in Oligomerization

The four Rep proteins of adeno-associated virus (AAV) orchestrate all aspects of its viral life cycle, including transcription regulation, DNA replication, virus assembly, and site-specific integration of the viral genome into the human chromosome 19. All Rep proteins share a central SF3 superfamily...

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Main Authors: Zarate-Perez, Francisco, Bardelli, Martino, Burgner, John W., Villamil-Jarauta, Maria, Das, Kanni, Kekilli, Demet, Mansilla-Soto, Jorge, Linden, R. Michael, Escalante, Carlos R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375335/
https://ncbi.nlm.nih.gov/pubmed/22719256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002764
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