Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome

Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep h...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Seyffert, Michael, Glauser, Daniel L., Tobler, Kurt, Georgiev, Oleg, Vogel, Rebecca, Vogt, Bernd, Agúndez, Leticia, Linden, Michael, Büning, Hildegard, Ackermann, Mathias, Fraefel, Cornel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621131/
https://ncbi.nlm.nih.gov/pubmed/26292324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01370-15
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