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Conversion of a single polypharmacological agent into selective bivalent inhibitors of intracellular kinase activity
Loss-of-function studies are valuable for elucidating kinase function and the validation of new drug targets. While genetic techniques, such as RNAi and genetic knockouts, are highly specific and easy to implement, in many cases post-translational perturbation of kinase activity, specifically pharma...
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| Publicat a: | ACS Chem Biol |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4943861/ https://ncbi.nlm.nih.gov/pubmed/26505072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00847 |
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