Conversion of a single polypharmacological agent into selective bivalent inhibitors of intracellular kinase activity

Loss-of-function studies are valuable for elucidating kinase function and the validation of new drug targets. While genetic techniques, such as RNAi and genetic knockouts, are highly specific and easy to implement, in many cases post-translational perturbation of kinase activity, specifically pharma...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Biol
Asıl Yazarlar: Gower, Carrie M., Thomas, Jason R., Harrington, Edmund, Murphy, Jason, Chang, Matthew E. K., Cornella-Taracido, Ivan, Jain, Rishi K., Schirle, Markus, Maly, Dustin J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943861/
https://ncbi.nlm.nih.gov/pubmed/26505072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00847
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