PIAS1 regulates mutant Huntingtin accumulation and Huntington’s disease-associated phenotypes in vivo

The disruption of protein quality control networks is central to pathology in Huntington’s disease (HD) and other neurodegenerative disorders. The aberrant accumulation of insoluble high molecular weight protein complexes containing the Huntingtin (HTT) protein and SUMOylated protein corresponds to...

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Vydáno v:Neuron
Hlavní autoři: Ochaba, Joseph, Monteys, Alex Mas, O’Rourke, Jacqueline G., Reidling, Jack C., Steffan, Joan S., Davidson, Beverly L., Thompson, Leslie M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942306/
https://ncbi.nlm.nih.gov/pubmed/27146268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.03.016
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