Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing

Phosphorylation has been generally thought to activate the SR family of splicing factors for efficient splice-site recognition, but this idea is incompatible with an early observation that overexpression of an SR protein kinase, such as the CDC2-like kinase 1 (CLK1), weakens splice-site selection. H...

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Udgivet i:Mol Cell
Main Authors: Aubol, Brandon E., Wu, Guowei, Keshwani, Malik M., Movassat, Maliheh, Fattet, Laurent, Hertel, Klemens J., Fu, Xiang-Dong, Adams, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941815/
https://ncbi.nlm.nih.gov/pubmed/27397683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.034
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