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Applying the Brakes to Multi-Site SR Protein Phosphorylation: Substrate-Induced Effects on the Splicing Kinase SRPK1

To investigate how a protein kinase interacts with its protein substrate during extended, multi-site phosphorylation, the kinetic mechanism of a protein kinase involved in mRNA splicing control was investigated using rapid quench flow techniques. The protein kinase SRPK1 phosphorylates approximately...

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Hlavní autoři: Aubol, Brandon E., Adams, Joseph A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153611/
https://ncbi.nlm.nih.gov/pubmed/21728354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2007993
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