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Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex

The Arp2/3 (Actin-related proteins 2/3) complex is activated by WASP (Wiskott–Aldrich syndrome protein) family proteins to nucleate branched actin filaments that are important for cellular motility. WASP recruits actin monomers to the complex and stimulates movement of Arp2 and Arp3 into a “short-pi...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Rodnick-Smith, Max, Luan, Qing, Liu, Su-Ling, Nolen, Brad J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941453/
https://ncbi.nlm.nih.gov/pubmed/27325766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517798113
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