A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models

Single-chain variable fragments (scFvs) expressed as “intracellular antibodies” (intrabodies) can target intracellular antigens to hamper their function efficaciously and specifically. Here we use an intrabody targeting the E6 oncoprotein of Human papillomavirus 16 (HPV16) to address the issue of a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Amici, Carla, Visintin, Michela, Verachi, Francesca, Paolini, Francesca, Percario, Zulema, Di Bonito, Paola, Mandarino, Angela, Affabris, Elisabetta, Venuti, Aldo, Accardi, Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941259/
https://ncbi.nlm.nih.gov/pubmed/26788990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6925
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