Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors

BACKGROUND: The oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins produced during viral infection. The oncoproteins interfere with cellular homeostasis by promoting proliferation, inhibiting apoptosis and blocking epitheli...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Paolini, Francesca, Amici, Carla, Carosi, Mariantonia, Bonomo, Claudia, Di Bonito, Paola, Venuti, Aldo, Accardi, Luisa
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825221/
https://ncbi.nlm.nih.gov/pubmed/33485370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01841-w
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