Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors

BACKGROUND: The oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins produced during viral infection. The oncoproteins interfere with cellular homeostasis by promoting proliferation, inhibiting apoptosis and blocking epitheli...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Paolini, Francesca, Amici, Carla, Carosi, Mariantonia, Bonomo, Claudia, Di Bonito, Paola, Venuti, Aldo, Accardi, Luisa
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825221/
https://ncbi.nlm.nih.gov/pubmed/33485370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01841-w
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