A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models

Single-chain variable fragments (scFvs) expressed as “intracellular antibodies” (intrabodies) can target intracellular antigens to hamper their function efficaciously and specifically. Here we use an intrabody targeting the E6 oncoprotein of Human papillomavirus 16 (HPV16) to address the issue of a...

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Udgivet i:Oncotarget
Main Authors: Amici, Carla, Visintin, Michela, Verachi, Francesca, Paolini, Francesca, Percario, Zulema, Di Bonito, Paola, Mandarino, Angela, Affabris, Elisabetta, Venuti, Aldo, Accardi, Luisa
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941259/
https://ncbi.nlm.nih.gov/pubmed/26788990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6925
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