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Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506

Human FKBP25 (hFKBP25) is a nuclear immunophilin and interacts with several nuclear proteins, hence involving in many nuclear events. Similar to other FKBPs, FK506 binding domain (FKBD) of hFKBP25 also binds to immunosuppressive drugs such as rapamycin and FK506, albeit with a lower affinity for the...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Prakash, Ajit, Rajan, Sreekanth, Yoon, Ho Sup
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941220/
https://ncbi.nlm.nih.gov/pubmed/26749369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2875
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