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Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52
As co-chaperones of Hsp90 (heat-shock protein 90), FKBP51 (FK506-binding protein of 51 kDa) and FKBP52 (FK506-binding protein of 52 kDa) act as antagonists in regulating the hormone affinity and nuclear transport of steroid receptor complexes. Exchange of Leu(119) in FKBP51 for Pro(119) in FKBP52 ha...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060953/ https://ncbi.nlm.nih.gov/pubmed/24749623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140232 |
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