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Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52
As co-chaperones of Hsp90 (heat-shock protein 90), FKBP51 (FK506-binding protein of 51 kDa) and FKBP52 (FK506-binding protein of 52 kDa) act as antagonists in regulating the hormone affinity and nuclear transport of steroid receptor complexes. Exchange of Leu(119) in FKBP51 for Pro(119) in FKBP52 ha...
Shranjeno v:
| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Portland Press Ltd.
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060953/ https://ncbi.nlm.nih.gov/pubmed/24749623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140232 |
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