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Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6

The primary known physiological function of FKBP12.6 involves its role in regulating the RyR2 isoform of ryanodine receptor Ca(2+) channels in cardiac muscle, pancreatic β islets and the central nervous system. With only a single previously reported X-ray structure of FKBP12.6, bound to the immunosu...

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Hlavní autoři: Chen, Hui, Mustafi, Sourajit M., LeMaster, David M., Li, Zhong, Héroux, Annie, Li, Hongmin, Hernández, Griselda
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949516/
https://ncbi.nlm.nih.gov/pubmed/24598733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004713032112
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