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Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists
BACKGROUND AND PURPOSE: Biased GPCR ligands are able to engage with their target receptor in a manner that preferentially activates distinct downstream signalling and offers potential for next generation therapeutics. However, accurate quantification of ligand bias in vitro is complex, and current b...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940816/ https://ncbi.nlm.nih.gov/pubmed/26791140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13441 |
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