Endothelin‐1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

BACKGROUND AND PURPOSE: Endothelin‐1 (ET‐1) is increased in patients with sickle cell disease and may contribute to the development of sickle cell nephropathy. The current study was designed to determine whether ET‐1 acting via the ET(A) receptor contributes to renal injury in a mouse model of sickl...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Brett Heimlich, J, Speed, Joshua S, O'Connor, Paul M, Pollock, Jennifer S, Townes, Tim M, Meiler, Steffen E, Kutlar, Abdullah, Pollock, David M
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940621/
https://ncbi.nlm.nih.gov/pubmed/26561980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13380
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